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The stress-induced activation of ANS and endocrine outputs for a timely mobilization of energy resources are necessary for survival

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When it comes to the development of medications for ASD, large-scale cooperation between researchers and industry is finally beginning to deal with some of the most significant barriers

When immune cells adopt a proinflammatory metabolic phenotype, for example M1-dominant macrophages, elevated ROS production and disrupted iron homeostasis often predispose both these cells and surrounding tissues to ferroptosis

Mechanistically, activation of PARP1 in calcified VSMCs elevates POLG PARylation levels, triggering PARylation-dependent ubiquitination and subsequent downregulation of POLG